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THF plays an important role in DNA synthesis, so reduced availability of THF results in ineffective production of cells with rapid turnover, in particular red blood cells, and also intestinal wall cells which are responsible for absorption

As much as your body can produce this element, the process could be limited by age, stress, exposure to chemicals, radiation, and unhealthy diets

This dual barrier explains decades of clinical trials showing near-universal resistance of MSS CRC to immune checkpoint blockade

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